Visible-Light-Driven Synergistic Se/Fe Catalysis for the Synthesis of 2‑Aminoquinoline Derivatives

A visible-light-driven Se/Fe synergistic catalytic reaction between isocyanides and amines has been developed, employing air as the terminal oxidant. This efficient strategy offers facile access to 2-aminoquinoline scaffolds. The use of cost-effective and readily available Fe(OTf)3 modulates the selenium catalyst’s oxidation state, enhancing the method’s environmental friendliness and practicality. The protocol is further distinguished by its good yields, broad substrate scope, and mild reaction conditions.