Whole blood DNA methylomes of 958 healthy adults from the Milieu Intérieur cohort

DNA methylation, one of the most studied epigenetic marks in humans, is associated with several non-communicable diseases, including multiple sclerosis, type 2 diabetes and cardiovascular disease, and may thus serve as a valuable biomarker of disease status. Yet, the factors that drive epigenetic variation in humans, particularly those relating to the immune system, remain to be fully characterized. To investigate factors impacting population variation in DNA methylation, we generated whole blood-derived DNA methylation profiles for 958 healthy adults of the Milieu Intérieur cohort at 866,836 CpG sites of the Illumina Infinium MethylationEPIC array. The data that can be accessed on this webpage include 2,176 raw Illumina IDAT files, as well as the full matrix of 958 non-transformed M-values, in the RDS format.