Gene expression profile at single cell level of Mycn-nGEMM mouse neuroblastoma tumors and their tumor microenvironment

Neuroblastomas are highly heterogeneous tumors originating from neural crest-derived cells destined to form the sympathetic nervous system. We used single cell RNA sequencing (scRNA-seq) to analyze the tumor microenvironment of Mycn-nGEMM mouse neuroblastoma. Overall design: Mycn-nGEMM tumors were enzymatically digested and single-cell FACS sorted for scRNA-seq.