Translational regulation of RANKL by CPEB2 regulates mammary gland development and luminal tumorigenesis (Affymetrix Microarrays). Translational regulation of RANKL by CPEB2 regulates mammary gland development and luminal tumorigenesis (Affymetrix Microarrays)

Here we show that the RNA-binding protein CPEB2 controls synthesis of RANKL, thereby modulating epithealial proliferation, differentiation and breast cancer outcome Overall design: Mouse array in duplicates of freshly sorted mammary epithelial populations: myoepithelial (Epcam_low and CD49f_high) and luminal (Epcam_high and CD49f_low). The sorted luminal subpopulations were non-clonogenic luminal (Sca1+CD49b-), ductal progenitors (Sca1+CD49b+) and alveolar progenitors (Sca1-Cd49b+).