<b>Negative regulation of reassortant canine influenza virus replication and key site identification in porcine and ferret bronchial epithelial cell lines</b>

This dataset contains raw experimental data from virus replication kinetics and cytokine expression analyses conducted in <i>hTERT-FBEC</i> (ferret bronchial epithelial cells) and <i>hTERT-PBEC</i> (pig bronchial epithelial cells) using various influenza virus strains. The data are organized into four Excel files:<b>FBEC-cytokine expression:</b><br>This file contains the cytokine expression data (including IL-1β, IL-6, IL-10, TNF-α, and IFN-α) for all influenza virus strains tested in hTERT-FBEC cells. The virus strains include 21 reassortant canine influenza strains, 4 control influenza strains, and 1 reassortant canine influenza strain constructed in this study.<b>PBEC-cytokine expression:</b><br>This file contains cytokine expression data (including IL-1β, IL-6, IL-10, TNF-α, and IFN-α) for the same set of influenza virus strains tested in hTERT-PBEC cells.<b>FBEC-growth curve:</b><br>This file contains virus replication kinetics data for all influenza virus strains in hTERT-FBEC cells, showing the growth curves across different time points.<b>PBEC-growth curve:</b><br>This file contains virus replication kinetics data for all influenza virus strains in hTERT-PBEC cells, showing the growth curves across different time points.These files provide detailed, unprocessed numerical data that form the basis for the analysis of influenza virus replication dynamics and cytokine responses in the manuscript. For more information on the experimental setup and analysis, please refer to the methods section of the manuscript.本数据集包含以多种流感病毒毒株为受试对象，在hTERT-FBEC（雪貂支气管上皮细胞）与hTERT-PBEC（猪支气管上皮细胞）中开展的病毒复制动力学及细胞因子表达分析的原始实验数据。本数据集整理为四个Excel文件： **FBEC-细胞因子表达**：该文件包含在hTERT-FBEC细胞中测试的所有流感病毒毒株的细胞因子表达数据（涵盖IL-1β、IL-6、IL-10、TNF-α及IFN-α）。受试毒株包括21株重配犬流感毒株、4株对照流感毒株，以及本研究构建的1株重配犬流感毒株。 **PBEC-细胞因子表达**：该文件包含在hTERT-PBEC细胞中，使用同一批流感病毒毒株测得的细胞因子表达数据（涵盖IL-1β、IL-6、IL-10、TNF-α及IFN-α）。 **FBEC-生长曲线**：该文件包含所有流感病毒毒株在hTERT-FBEC细胞中的病毒复制动力学数据，展示了不同时间节点下的生长曲线。 **PBEC-生长曲线**：该文件包含所有流感病毒毒株在hTERT-PBEC细胞中的病毒复制动力学数据，展示了不同时间节点下的生长曲线。 上述文件包含详实的未加工数值数据，为本文稿件中流感病毒复制动力学与细胞因子应答分析提供了核心基础。如需了解实验设计与分析方法的更多细节，请参阅本文稿件的材料与方法部分。