Over-represented TFBSs and other novel motifs in boundary sequences.

The second column indicates whether the TFs corresponding to the over-represented TFBSs have been reported to express in human brain. The two numbers in the 3th–4th columns are the p-values in the two-step hypothesis test in the corresponding fragment (we use p1 and p2 to represent the upper and lower value respectively). Only the TFBS with p1 less than Bonferroni-adjusted p-value cutoff 0.01 and p2 less than 0.01 is regarded as a significant TFBS in the fragment, and is marked in bold. Here we regard TFBSs or novel motifs that are both significant in O1 and P1 fragments as the over-represented TFBSs or over-represented novel motifs in boundaries of U-CGIs.