Recruitment of TRAF6/TRAF2 to IPS-1

IPS-1 interacts with TRAF2 and TRAF6 through its consensus TRAF-interaction motif (TIM) (TRAF2 143-PVGET-147 and TRAF6 153-PGENSE-158 & 455-PEENEY-460). Although IPS-1 can bind to both TRAF6 and TRAF2, TRAF2 binding is not required for IPS-1 activation of NF-kB.

IPS-1通过其共识TRAF相互作用基序（TIM）（TRAF2 143-PVGET-147和TRAF6 153-PGENSE-158 & 455-PEENEY-460）与TRAF2和TRAF6相互作用。尽管IPS-1可以与TRAF6和TRAF2结合，但TRAF2的结合并非IPS-1激活NF-kB所必需。