(Released July 2024) Tuberculosis Infected Marmosets

The MARM-TB-FDT dataset contains the PET/CT scans from common marmosets infected with Mycobacterium tuberculosis (MTB) and imaged with FDG ([¹⁸F]Fluorodeoxyglucose) or FDT ([¹⁸F]Fluorodeoxytrehalose) during experiments to characterize the distribution of FDT into marmoset tissues during MTB infection. Trehalose is incorporated into the outer leaflet of MTB and so can, when labeled, be captured in bacteria, and infected cells where MTB are present. FDT is a 18 F positron-emitting non-mammalian disaccharide trehalose that can be used as probe to detect regions of mycobacterium infection. It was developed in a collaboration between Oxford University and the US National Institute of Allergy and Infectious Disease. This data set documents the preclinical non-human primate scans collected during this initial characterization of the probe’s performance. The dataset consists of multiple scans of 10 common marmosets (both infected and naïve) and two MTB- infected cynomolgus macaques. A excel read-me file lists the scans available in the data set.