Decreased GLUT2 expression and defective glucose uptake in MODY3 human iPSC-derived beta cells
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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To evaluate the impact of HNF1A+/H126D mutation on pancreatic beta cell biology, we performed RNA-Seq analyses on the day 20 endocrine progenitor cells which maximally expressed HNF1A. Principal component analysis (PCA) plot showed distinct clustering of WT cells separate from the mutant cells, indicating that the HNF1A+/H126D mutation has an impact on global transcript profiles in the cells. A volcano plot demonstrated that there were 1724 genes downregulated and only 583 genes upregulated in mutant cells as compared to WT cells. Gene ontology (GO) analysis revealed that the genes that were downregulated in mutant cells were largely involved in biological processes such as localization, transport and secretion and molecular functions such as protein binding and transporter activity.
提供机构：
IMCB, A*STAR
创建时间：
2022-02-20
