Atypical teratoid rhabdoid tumor: Pediatric brain tumor

Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant brain tumor that inactivates the SMARCB1 gene, which plays a critical role in genomic transcriptional control. In this project, we analyzed the genomic and transcriptomic profiles of human AT/RTs to discover new druggable targets. Multiplanar sequencing analyses were performed using 4 AT/RT tissues. Whole exome sequencing revealed that the AT/RT genome is extremely stable except for the inactivation of SMARCB1.