Code for Sex-Based Differences in Placental Epigenetic Profiles Related to Gestational Age: An NIH ECHO Meta-Analysis

This project explored associations between gestational age at birth and placental DNA methylation by infant sex. Four independent birth cohorts from the NIH ECHO Program carried out coordinated epigenome-wide association studies (EWAS) according to a pre-specified analytic plan. The summary statistics from these EWASs were then meta-analyzed. The R scripts used to conduct the coordinated EWASs and meta-analyses are provided here.The scripts are labelled first with a number, indicating the order in which they should be run, followed by a description of the specific task accomplished by the code. If scripts were specific to a certain infant sex (females or males) or model type (unadjusted or cell-type adjusted), those labels are also included in the file names.