RNA-seq for cytosine base editors with DNA damage minimization 2

NIAID Data Ecosystem2026-05-01 收录

碱基编辑器RNA脱靶检测

基因编辑安全性

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP455727 数据链接链接失效反馈

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资源简介：

RNA C-to-U edits of cytosine base editors with DNA damage minimization 2

创建时间：

2024-01-01

IDLV capture for gRNA off-target analysis

CRISPR脱靶检测

基因编辑安全性

Vector capturing was used for experimental identification of potential off-target sites of 2 gRNA targeting alpha globin genes Overall design: K562 cells were transduced with an Integrase-defective l

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Cas12a base editors induce efficient and specific editing with low DNA damage response (DNA targeted sequencing)

CRISPR碱基编辑优化

基因编辑安全性

The advent of base editors (BEs) holds a promising potential in correcting pathogenic-related point mutations to treat relevant diseases. Unexpectedly, Cas9 nickase (nCas9) derived BEs lead to DNA dou

NIAID Data Ecosystem20

CRISPR off-target enrichement Match1

CRISPR脱靶效应

基因编辑安全性

CRISPR off-target enrichement Match1 site

NIAID Data Ecosystem20

DataSheet_1_Efficacy and safety of universal (TCRKO) ARI-0001 CAR-T cells for the treatment of B-cell lymphoma.pdf

通用型CAR-T疗法

基因编辑安全性

Autologous T cells expressing the Chimeric Antigen Receptor (CAR) have been approved as advanced therapy medicinal products (ATMPs) against several hematological malignancies. However, the generation

NIAID Data Ecosystem30

Mapping of microhomologies at CRISPR/Cas9 deletions. Mapping of microhomologies at CRISPR/Cas9 deletions

基因编辑安全性

基因组缺失突变分析

The CRISPR system is widely used in genome editing for biomedical research. Here, using either dual paired Cas9D10A nickases or paired Cas9 nuclease we characterise unintended larger deletions at on-t

NIAID Data Ecosystem20

RNA-seq for cytosine base editors with DNA damage minimization 2

资源简介：

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