District-week notifiable infectious disease surveillance data for Khyber Pakhtunkhwa, Pakistan, 2023-2026

A structured, long-format panel dataset of district-week notifiable infectious disease case counts for Khyber Pakhtunkhwa province, Pakistan, extracted from 164 weekly Integrated Disease Surveillance and Response (IDSR) Public Health Bulletins published by the National Institute of Health, Pakistan, between April 2023 and July 2026. The dataset comprises 59,824 district-week-condition observations spanning 44 canonical district- and sub-division-level reporting units and 16 notifiable conditions. Six conditions - acute diarrhoea (non-cholera), malaria, influenza-like illness, acute lower respiratory infection in children under five, bloody diarrhoea and typhoid - are reported in all 164 bulletins. Ten further conditions appear only in a subset of weeks, because from 2023 week 32 the source table reports the highest-ranking conditions by provincial case total rather than a fixed set, producing 106 distinct column orderings across the corpus. Absence of a rotating condition from a given week indicates non-inclusion in that week's ranked columns, not a zero count. The deposit documents this rotating-column structure explicitly and includes a time-scoped district crosswalk resolving administrative-boundary instability over the study period, including one reporting label whose underlying geography is redefined mid-series. Machine-readable flags record every known data-quality issue, including a duplicated source table, four rows corrected for a dropped-cell transcription error, and weeks in which district rows do not reconcile with the printed provincial total. The raw transcribed source text and the parser that produces the published files from it are both included, so the path from source to panel is fully reproducible. No comparable structured, validated dataset derived from Pakistan's national disease surveillance bulletins is currently available in the public domain.