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Characterization of melanoma TILs and identification of mimotope peptide antigens

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NIAID Data Ecosystem2026-03-13 收录
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We sequenced TCRs of tumor-infiltrating T cells to characterize the T cell response following combination immunotherapy of murine melanoma. After identifying a dominant antigen recognized by expanded TILs, we then used yeast displayed peptide-MHC libraries to identify mimotopes to enhance the T cell response.

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2022-02-25
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