Klebsiella pneumoniae Genome sequencing. Klebsiella pneumoniae

CRKP pose a serious threat to public health.It is characteristiced by high mortality and difficulties in clinical treatment;understand the virulence regulation mechanism is necessary to provide theoretical basis for clinical prevention and treatment.CRP is an important global regulator of pathogenic bacteria. In literature and our early research indicated that :the virulence ofCRKP is closely related to CRP, which is positive expression in CRKP. the expression of entB and ybtS are major mechanisms related to virulence.however,whether CRP affect the virulence of CRKP by regulate entB and ybts is unknown .