Association between genetic variants at chromosome 1q41 and high myopia in the five Asian cohorts.

aMA, minor allele. bGWAS cohorts; SCES - Singapore Chinese Eye Study; SCORM - Singapore Cohort study of the Risk factors for Myopia; SiMES - Singapore Malay Eye Study. cThe sample sizes for each study denote the number of high-myopia cases versus controls. For the Japan dataset 1, high myopia, AL≥28mm for both eyes; controls, general healthy population; For the Japan dataset 2, SCES, and SiMES, high myopia, SE≤−9.0 D for either eye; controls, SE≥−3.0 D for both eyes; For SCORM children, high myopia, SE≤−6.0 D for either eye; controls, SE≥−1.0 D for both eyes. dOR, odds ratio per copy of minor allele. ePhet, P-value for heterogeneity by Cochran's Q test across five study cohorts.