Study of MeCP2 binding and accessibity of chromatin in absence and presence of MeCP2 using ATAC-seq

ATAC-seq was performed to study changes in chromatin openness in the MeCP2 knock-outs and overexpressions. Additionally data was used to visualise the foorprint of MeCP2 bound to chromatin in vivo. Overall design: ATAC-seq was performed on LUHMES-derived neurons including: controls, MeCP2 KO and OE.