The expression signatures of circRNA in MCT-induced pulmonary arterial hypertension rat

To investigate the underlying mechanism of pulmonary hypertension, the model of monocrotaline (MCT)-treated pulmonary arterial hypertension (PAH) rats were constructed to detect the differentially expressed profile of circRNAs in lung tissue of PAH rat. The whole genome microarray expression profiling analysis as a discovery platform have been employed to identify genes difference. The male rats were treated with monocrotaline (MCT) to induce pulmonary arterial hypertension model. One dose of MCT (60 mg/kg) was injected Intraperitoneally into animals. Control rats were injected with the equivalent volume of dissolvent solution according to their weights. After 4 weeks late, the lung tissue was collected to detect the circRNA expression profile.