Functional analysis of a bacitracin resistant determinant located on ICECp1, a novel Tn916-like element from a conjugative plasmid in Clostridium perfringens. bacitracin resistance in Clostridium perfringens

Bacitracins are mixtures of structurally related cyclic polypeptides with clinically useful antibiotic properties. They act by indirectly interfering with the biosynthesis of the bacterial cell wall. In this study, we analysed an avian necrotic enteritis strain of Clostridium perfringens that was resistant to bacitracin and produced NetB toxin. We identified a putative bacitracin resistance locus that resembled a bacitracin resistance determinant from Enterococcus faecalis. It contained the structural genes bcrABD and a putative regulatory gene, bcrR.