Rad50

ENCODES a protein that exhibits double-stranded DNA binding; protein-containing complex binding; 3'-5' exonuclease activity (ortholog); INVOLVED IN blocking of symbiont entry into host cell; DNA damage response; heart development; PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; homologous recombination pathway of double-strand break repair; non-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH liver cirrhosis; myocardial infarction; asthma (ortholog); FOUND IN chromatin; condensed nuclear chromosome; inclusion body; INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroperoxycyclophosphamide

编码一种具有双链DNA结合特性的蛋白质；蛋白质复合物结合；3'-5'外切酶活性（同源酶）；参与阻止共生体进入宿主细胞；DNA损伤反应；心脏发育；参与着阿托希亚-坦吉厄克突变（ATM）信号通路；双链断裂修复的同源重组途径；双链断裂修复的非同源末端连接途径；与肝硬化、心肌梗死、哮喘（同源酶）相关；存在于染色质中；浓缩的核染色体；包涵体；与1,3-二硝基苯；2,3,7,8-四氯二苯并二噁英；4-羟基过氧环磷酰胺相互作用。