One-Pot Synthesis of α‑Carbonyl Bicyclic Furans via a Sequential Diels–Alder/5-Exo-Dig Cyclization/Oxidation Reaction

A new one-pot approach to construct α-carbonyl bicyclic furans from easily accessible diynones is described. This reaction sequence proceeds via a Diels–Alder cycloaddition reaction catalyzed by dimethylaluminum chloride followed by a 5-exo-dig cyclization/oxidation reaction catalyzed by copper­(II) chloride. This methodology generates α-carbonyl-functionalized dihydro­isobenzo­furan derivatives in good to excellent yields.