Bibliometric analysis of studies on the association between Diabetes Mellitus and Parkinson’s Disease

Background:The recognition of a link between impaired insulin signaling in the brain and neurodegenerative disorders has sparked heightened interest in exploring the relationship between diabetes mellitus (DM) and Parkinson’s disease (PD). Numerous studies have indicated possible associations between these conditions from multiple perspectives. As a result, a bibliometric and visualization analysis employing CiteSpace is essential to map the current research landscape, identify key areas of focus, and highlight emerging research frontiers concerning the DM-PD relationship.Purpose: To examine the present research landscape and identify emerging patterns in studies focusing on the relationship between DM and PD through the use of CiteSpace.Methods: Studies concerning the association between DM and PD published between 1991 and 2024 were retrieved from the Web of Science Core Collection database through a predefined search strategy. After filtering out unrelated studies, the relevant literature was processed using CiteSpace to conduct a bibliometric and visualization analysis.Results: A total of 3755 studies exploring the association between DM and PD were retrieved, with the annual publication rate reaching its highest in 2022. The United States led in the number of publications. The University of London emerged as the most prolific institution, while the University of California System demonstrated the highest level of institutional collaboration. Christian Holscher contributed the most publications, whereas Athauda D was recognized for the highest citation frequency. Journals based in the United States were cited the most extensively. The primary research hotspots regarding DM and PD encompassed risk factors, associated diseases, study types, pathological mechanisms, and biomarker investigations. Research into gut microbiota has surfaced as a developing field.Conclusion: This study provides an overview of the research landscape and developmental trends related to the association between DM and PD from 1991 to 2024, offering valuable insights for researchers in determining future research directions.