Chronically radiation-exposed survivor GBM cells display poor response to Chk1 inhibition.

To investigate radiation response of reccurent glioblastoma models after radiotherapy, we have utilized clinically relevant radioresistant cell model. We have generated to radiation survivor GBM population from 1 cell line and 1 primary cell line. To investigate transcriptomic alterations we have performed RNA-seq to our both naive and IR survivor samples as triplicates. Overall design: Examining transcriptomic alterations in radiation-survivor and naive GBM cells.