SUMOylation in adrenal cortex homeostasis

Identify genetic programs impacted by increasing protein SUMOylation and controlling adrenal cortex zonation We used adrenal glands from pubescent female and male mice having a genetically induced global SUMOylation. The mutant mice bear adrenal-specific deletion of the Senp2-floxed conditional allele that encodes a deSUMOylase.