c-Myc Transcriptionally Amplifies Sox2 Target Genes to Regulate Self-Renewal in Multipotent Otic Progenitor Cells [ChIP-Seq]. Mus musculus
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA264315
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资源简介：
An immortalized multipotent otic progenitor (iMOP) cell was generated by transient expression of c-Myc in Sox2-expressing otic progenitor cells. The procedure activated endogenous c-Myc expression in the cells and amplified existing Sox2-dependent transcripts to promote self-renewal. Downregulation of c-Myc expression following growth factor withdrawal resulted in a molecular switch from self-renewal to otic differentiation. Overall design: ChIP-Seq was accomplished by immunoprecipitating endogenous RNA PolII, c-Myc and Sox2
创建时间：
2014-10-20
