Supplementary Data File 1 from Rationally Designed Transgene-Encoded Cell-Surface Polypeptide Tag for Multiplexed Programming of CAR T-cell Synthetic Outputs
Due to the low-throughput process of systematically designing and functionally testing chimeric antigen receptors (CARs), only a small set of immune signaling domains have been thoroughly explored, de
The Mission Bio Tapestri platform allows for targeted single-cell DNA sequencing based on a microfluidic droplet technology. A custom Tapestri amplicon panel was designed to capture 56 potential ABE t
Higher and lower affinity self-reactive CD4 T cells are seen in autoimmunity; however, their individual contribution to disease remains unclear. We addressed this question using peptide-MHCII chimeric
Multiple myeloma is a plasma cell malignancy that is currently incurable with conventional therapies. Following the success of CD19-targeted chimeric antigen receptor (CAR) T-cells in leukemia and lym
Viruses and virally-derived particles have the intrinsic capacity to deliver molecules to cells, but the difficulty of readily altering cell-type selectivity has hindered their use for therapeutic del