Microbiome-derived metabolites alleviate chronic pain in a reserpine-induced model of fibromyalgia.

Animals were put on specific diets 28 days before the first injection of reserpine or vehicle to provide sufficient time for change in the microbiota to occur. An equal number of male and female rats were grouped into either Gut-Microbiota Acetogenic Diet (GMAD) or control diet (AIN93G) (Specialty Feeds (WA, Australia).