ROC-plot analysis curves comparing patients according to their postsurgical relapse at the optimum cutoffs identified by the ROC model for all soluble immune mediators studied.

ROC plot curves at optimum cutoffs for each immune mediator were calculated and tested for their ability to detect postsurgical tumor recurrences according to their sensitivity and specificity. Sensitivity and Specificity: IL-1 (0,88 and 0,68); IL-6 (0,88 and 0,59); IL-10 (1 and 0,40); TNF-a (1 and 0,05); CCL2 (0,77 and 0,5); CXCL8 (1 and 0,64); VEGF: (1 and 0,66); PTX-3: (0,55 and 0,90). ROC cut-off values: IL-1 (0,81 pg/ml), IL-6 (5,86 pg/ml), IL-10 (4,14 pg/ml), TNFa (49,72 pg/ml), CCL2 (38,03 pg/ml), CXCL8 (7,01 pg/ml), VEGF (39,03 pg/ml), PTX3 (13,68 pg/ml). (PDF)