Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair
收藏NIAID Data Ecosystem2026-05-01 收录
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https://data.mendeley.com/datasets/7wzsyk6355
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In the present study we leverage the power of mass cytometry by time-of-flight (CyTOF) to define, at the single-cell level, mesenchymal bone and marrow senescent cells in mice during fracture. Three main CyTOF experiments were performed:
1) TIMECOURSE: Assessment of senescent cell burden in skeletal and immune cell populations during a 28-day timecourse of fracture healing.
2) P21-ATTAC: Identification of cell populations targeted through p21+ cell clearance in p21-ATTAC mice.
3) OCH-STEM: In-depth assessment of osteochondroprogenitor (OCH) cells through expanded panel, including skeletal stem cell (SSC) markers.
创建时间：
2024-03-20
