Single-cell transcriptomics of precursor lung adenocarcinoma reveals intratumoral heterogeneity and shifting immune network

We conducted a multi-omics analysis including single-cell RNA transcriptome, single-cell T cell receptor (scTCR), whole exome sequencing and multiplex immunohistochemistry (mIHC) to decipher single cell atlas of precursor lung adenocarcinoma and mechanisms of diverse immune cells during precursor lesions development in hopes of digging out potential therapeutic targets. 78 (62 scRNA and 16 scTCR)