Dual-SignalChemicalExchangeSaturationTransfer(Dusi-CEST):An EfficientStrategyforVisualizingDrugDeliveryMonitoringinLiving Cells
收藏中国科学院兰州化学物理研究所科学数据中心2026-01-13 更新2026-01-17 收录
下载链接：
https://ggjsfwdata.licp.cn/dataDetails/7c5ac35168e74e68939b80349cc0a535
下载链接
链接失效反馈官方服务：
资源简介：
We report a dual-signal chemical exchange satu-
ration transfer (Dusi-CEST) strategy for drug delivery and
detection in living cells. The two signals can be detected by
operators in complex environments. This strategy is demonstrated
on a cucurbit[6]uril (CB[6]) nanoparticle probe, as an example.
The CB[6] probe is equipped with two kinds of hydrophobic
cavities: one is found inside CB[6] itself, whereas the other exists
inside the nanoparticle. When the probe is dispersed in aqueous
solution as part of a hyperpolarized 129Xe NMR experiment, two
signals appear at two different chemical shifts (100 and 200 ppm).
These two resonances correspond to the NMR signals of 129Xe in
the two different cavities. Upon loading with hydrophobic drugs,
suchaspaclitaxel,forintracellulardrugdelivery,thetworesonances
undergo significant changes upon drug loading and cargo release, giving rise to a metric enabling the assessment of drug delivery
success. The simultaneous change of Dusi-CEST likes a mobile phone that can receive both LTE and Wi-Fi signals, which can help
reduce the occurrence of false positives and false negatives in complex biological environments and help improve the accuracy and
sensitivity of single-shot detection.
提供机构：
中国科学院兰州化学物理研究所科学数据中心
创建时间：
2026-01-13
