Clinical responses to infection.
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(A–C) Two weeks after booster vaccination, ferrets were challenged intranasally with 106 PFU of Perth/16. (D–F) Unvaccinated ferrets were challenged intranasally with 1×106 PFU of NY/21 or Perth/16. (A, D) Body weight and (B, E) temperature were measured daily. Data shown are normalized to the individual animals’ weight or temperature on the day of challenge (day 0). (C, F) Nasal washes were obtained on days 0–9 and virus titers in the nasal washes were measured. Error bars represent 95% confidence intervals. “Mock”, unvaccinated mock-infected animals; “Naïve”, unvaccinated animals challenged with Perth/16; “TIV”, vaccinated animals challenged with Perth/16. “H3N2”, unvaccinated animals challenged with Perth/16; “H1N1pdm”, unvaccinated animals challenged with NY/21. † indicates p
创建时间：
2016-02-23
