Data of An antibody to ITGB4 protects Zika virus-related testicular atrophy

ITGB4 is highly expressed in peritubular myoid cells, the initial ZIKV replication site after capillary entry. Viral spread from these cells to Sertoli cells disrupts the blood–testis barrier and permits germ cell infection. Targeting ITGB4 thus offers a promising approach to safeguard male fertility and block ZIKV sexual transmission.