Establishment of commercial taxol-production-tech by culturing Taiwan yew cells in bioreactors (2/3) - Transgenic cell culture

The company cooperated with Taiwan Forestry Research Institute has been decide to produce taxol by bioreactors in Taiwan. To establish the scale up system between lab and commercial production of taxol is very important. This project tries to moitor factors that increase culture volume from 5-L to 20-L and 100-L bioreactor. This pilot study will be decrease the risk of commercial scale might met. Cell cultured in a 5-L bioreactor created by cooperated company worked well. The 20-L bioreactor was designed and produced by the company. The another important work in this project is to try the transgenic cells transformed with auxin, TS, and DBAT genes in suspension cultures to evaluate these cell lines with the better performance than normal cell cultures.