SaptioTemporal dynamics of macrophage heterogeneity after myocardial infarction. SaptioTemporal dynamics of macrophage heterogeneity after myocardial infarction

In this study, we attempted to identify the heterogeneity and temporal dynamics of leukocytes at single-cell level in mouse heart after inducing MI using the longitudinal single-cell RNA sequencing and spatial transcriptome sequencing. Overall design: To obtain a comprehensive landscape of immune cell profiling after ischemic injury of heart, we performed spatial transcriptome sequencing on mouse heart at 1, 3, 5, and 7 days after inducing MI.