Asymmetric Mannich Reaction of Isatin-Based Ketimines with α‑Diazomethylphosphonates Catalyzed by Chiral Silver Phosphate
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https://figshare.com/articles/dataset/Asymmetric_Mannich_Reaction_of_Isatin-Based_Ketimines_with_Diazo_methyl_phosphonates_Catalyzed_by_Chiral_Silver_Phosphate/3750075
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资源简介：
An
efficient asymmetric Mannich reaction of isatin-based ketimines
with α-diazomethylphosphonates has been developed using
a chiral binaphthanol-derived silver phosphate as the catalyst. This
reaction allowed the construction of a series of chiral oxindoles
bearing a quaternary stereocenter and amino group at the C3 position
with up to 95% yields and 99% ee. Those products
could be further transformed into promising densely functionalized
compounds by merging of the oxindole and β-aminophosphonate.
创建时间：
2016-08-29
