Physiological parameters of heart and electrocardiography.

Body and heart weight (means±SEM) of TET-1 and NTg at 8-weeks old. Mean arterial blood pressure (mmHg, means±SEM) of TET-1 and NTg mice. LV/Hr, ratio of left ventricular wall wet weight to whole heart wet weight. RV/Hr, ratio of left ventricular wall wet weight to whole heart wet weight. Left ventricular walls of TET-1 were heavier than those of non-transgenic mice. Electrocardiographic (ECG) profiles of TET-1 and non-transgenic (NTg) mice. P-P and P-R intervals were calculated by time distance between respective peaks of ECG tracings. QRS intervals were measured from beginning to end of the QRS complex. P-R/P-P is the ratio of P-R interval to P-P interval. Electrical axis with (0°)–(90°) is defined as normal, (−1°)–(−90°) is defined as left axis deviation. TET-1 show increased P-R interval and left axis deviation. Values are expressed in means±SEM, N = 9–12.*P**P***P