TBX4
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This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human homolog of mouse Tbx4, which is closely linked to Tbx2 on mouse chromosome 11. Similarly this gene, like TBX2, maps to human chromosome 17. Expression studies in mouse and chicken show that Tbx4 is expressed in developing hindlimb, but not in forelimb buds, suggesting a role for this gene in regulating limb development and specification of limb identity. [provided by RefSeq, Jul 2008]
本基因属于一个在系统发育上保守的基因家族，该家族的基因共享一个共同的DNA结合域，即T-box域。T-box基因编码的转录因子参与了发育过程的调控。该基因是人类Tbx4基因的同源基因，Tbx4在鼠的第11号染色体上与Tbx2紧密相连。类似地，该基因，如同TBX2，定位于人类的第17号染色体上。对小鼠和鸡的表达研究显示，Tbx4在发育中的后肢中表达，但在前肢芽中不表达，这表明该基因在调节肢体发育和肢体身份的指定中扮演着一定的角色。[由RefSeq提供，2008年7月]
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