A 92-kDa human immunostimulatory protein.
收藏PubMed Central1994-08-30 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC44604/
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资源简介：
We purified to apparent homogeneity a human urinary glycoprotein of 92 kDa (HGP.92) that, administered intravenously at 250 micrograms/kg, fully protected mice against a lethal inoculum of Listeria monocytogenes. Since HGP.92 protected scid mice, which lack B and T lymphocytes, this increased resistance to Listeria did not appear to be lymphocyte mediated. Furthermore, inflammatory macrophages incubated with 6 nM HGP.92 inhibited the growth of Lewis carcinoma cells in vitro. These two activities appeared to depend on an oligosaccharide moiety, as they were lost after N-Glycanase treatment of HGP.92. Thus, the biological activity of HGP.92 was in some way related to a glycan moiety. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1994-08-30
