Fig.S2-GI-00311-2024R1-2ndSubmission.pdfSupplementary figures for the paper titled, "The multifaceted role of sirtuins in inflammatory bowel diseases"

Inflammatory Bowel Diseases (IBD) mainly involving the disease states of Ulcerative Colitis (UC) and Crohn’s disease (CD), are characterized by chronic, relapsing inflammation of the gastrointestinal tract. While existing treatments for IBD are generally supportive, they are not curative; underscoring the need to identify other causative agents that drive disease pathogenesis. Several studies have reported metabolic alterations in the pathogenesis of IBD. In all living cells, Nicotinamide Adenine Dinucleotide (NAD⁺) plays a pivotal role in the regulation of energy metabolism and cell signaling. Dysregulated NAD⁺ metabolism is also reported in IBD patients. Sirtuins, a protein family of post-translational modifiers, need NAD⁺ as a cofactor to perform enzymatic reactions such as deacylation and ADP-ribosylation of not only histones, but also of various other key cellular proteins. This review article is written to address the novel mechanisms by which sirtuins play a role in IBD pathogenesis, thus exposing a potential therapeutic role of this group of enzymes that might be useful in curtailing IBD and several other debilitating gastrointestinal inflammatory disorders.