CB-6644-resistant_CellTiterGlo_Luminescence

Dose Response Curves (CellTiter-Glo assay) for CB-6644. Luminescence of each CB-6644 treated sample was normalized to the luminescence of the DMSO treated sample. Cells were treated with CB-6644 for 72-96 hours. Each dot is the mean normalized luminescence ± SD. n = 2. Prior to treatment with CB-6644, cDNAs encoding wild type (WT) RUVBL1 or RUVBL2, or a CB-6644-resistant mutant: RUVBL1A62T or RUVBL2dF109, were stably expressed by lentiviral transduction.