The Chronic Kidney Disease in Children Cohort Study

Chronic kidney disease (CKD) is a life-long condition that often results in substantial morbidity and premature death due to complications from a progressive decrease in kidney function. The early detection of, and initiation of therapy for, CKD is key to delaying or preventing progression to end-stage renal disease (ESRD). The CKiD (Chronic Kidney Disease in Children, https://statepi.jhsph.edu/ckid/) study is a prospective cohort study of children with CKD that investigates risk factors and outcomes of the disease.

The study population consists of two cohorts. Cohort 1 includes 586 racially and ethnically diverse children recruited between the ages of 1 and 16 years with mild to moderately impaired kidney function (defined by an estimated GFR between 30-90 ml/min/1.73m²). Cohort 2 includes 305 children with mildly impaired kidney function (defined as an estimated GFR between 45-90 ml/min/1.73m²). At baseline, participants underwent a physical examination, in addition to assessments of kidney, cardiovascular, and neurocognitive symptoms and function. Similar measures of kidney function, neurocognitive function, markers of risk factors for cardiovascular disease, growth and other co-morbid conditions are assessed at regularly scheduled study visits. Biospecimens, including serum, plasma, and urine are also collected. The primary outcome measure is the rate of decline of GFR, which is measured repeatedly over time in cohort participants. A secondary outcome measure is the time to ESRD, defined by transplantation, dialysis, or a 50% decrease in GFR.

Baseline and follow-up biospecimens and data through July 31, 2018 are available from the Repository. The most recent data contains additional summary files related to nutrients and grip strength.