Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist GSK1482160

Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist GSK1482160 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-1-methyl-5-oxo-L-prolinamide, ... Authors: Oken, A.C, Ditter, I.A, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Mansoor, S.E. Deposit date: 2023-08-09 Release date: 2024-10-16 Last modified: 2025-05-28 Method: ELECTRON MICROSCOPY (2.41 Å) Cite: P2X 7 receptors exhibit at least three modes of allosteric antagonism. Sci Adv, 10, 2024