Effect of antibiotic-loaded chitosan nanodroplets on Enterococci isolated from chronic ulcers of the lower limbs

Dataset from the article Mazzaccaro D, Ticozzi R, D'Alessandro S, Delbue S, Nano G, Costa E, Argenziano M, Cavalli R, Prato M, Basilico N. Effect of antibiotic-loaded chitosan nanodroplets on Enterococci isolated from chronic ulcers of the lower limbs. Future Microbiol. 2020 Sep;15:1227-1236. doi: 10.2217/fmb-2019-0255. PMID: 33026879. <strong>Abstract </strong> <strong>Aim:</strong> To investigate the effect of a new platform of nanocarriers, called nanodroplets (NDs), to enhance the <em>in vitro</em> activity of vancomycin (Vm), against bacterial colonies isolated from chronic ulcers of the lower limbs. <strong>Materials &amp; methods:</strong> Oxygen-loaded nanodroplets (OLNDs) or oxygen-free nanodroplets (OFNDs) were loaded with Vm (Vm-OLNDs and Vm-OFNDs). MIC and minimal bactericidal concentrations were evaluated for Vm, OLNDs and OFNDs loaded with Vm, OLNDs and OFNDs. <strong>Results &amp; conclusion:</strong> Nanodroplets, either with or without oxygen, appeared as a suitable platform of antibiotic nanocarriers to enhance the antibacterial effects of Vm against <em>Enterococci</em>, with a decrease in both MIC and minimal bactericidal concentration against Vm-resistant <em>Enterococci</em> strains.