Crystal structure of mouse Galectin-3 in complex with small molecule inhibitor

Crystal structure of mouse Galectin-3 in complex with small molecule inhibitor Descriptor: (2R,3R,4R,5R,6S)-2-(hydroxymethyl)-6-[2-(2-methyl-1,3-benzothiazol-6-yl)-1,2,4-triazol-3-yl]-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxane-3,5-diol, Galectin-3, SODIUM ION, ... Authors: Kumar, A, Jinal, S, Raman, S, Ghosh, K. Deposit date: 2023-03-04 Release date: 2024-03-06 Last modified: 2024-09-25 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Identification of benzothiazole derived monosaccharides as potent, selective, and orally bioavailable inhibitors of human and mouse galectin-3; a rare example of using a S···O binding interaction for drug design. Bioorg.Med.Chem., 101, 2024