The frequencies of candidate genetic loci.

The most common allele for each locus is underlined.Abbreviation: HWE, Hardy–Weinberg equilibrium.aComparison between our data and Western data with pediatric ALL. Data for 15 loci was adopted from Ref. 10 and data of ITPA 94 C>A was from Ref. 9.bComparison between our data and normal Japanese data. Reference data was adopted by SNP searching on NCBI reference assembly (http://www.ncbi.nlm.nih.gov/snp/). Data for CYP3A4*1B was from Coriell Cell Repository samples and all the others were from Japanese data of the Hapmap project.cHardy-Weinberg equilibrium was reached after the A variant was excluded (P = 0.38).dVariant alleles : TPMT*1 (Wild type), TPMT*2 (238 G>C), TPMT*3A (460 G>A and 719 A>G), TPMT*3B (460 G>A), TPMT*3C (719 A>G).