RIDER NEURO MRI

RIDER Neuro MRI contains imaging data on 19 patients with recurrent glioblastoma who underwent repeat imaging sets.  These images were obtained approximately 2 days apart (with the exception of one patient, RIDER Neuro MRI-1086100996, whose images were obtained one day apart).   <p><u><strong>DCE‐MRI:</strong> </u> All 19 patients had repeat dynamic contrast‐enhanced MRI (DCE‐MRI) datasets on the same 1.5T imaging magnet.  On the basis of T2‐weighted images, technologists chose 16 image locations using 5mm thick contiguous slices for the imaging.  For T1 mapping, multi‐flip 3D FLASH images were obtained using flip angles of 5, 10, 15, 20, 25 and 30 degrees, TR of 4.43 ms, TE of 2.1 ms, 2 signal averages.  Dynamic images were obtained during the intravenous injection of 0.1mmol/kg of Magnevist intravenous at 3ccs/second, started 24 seconds after the scan had begun.  The dynamic images were acquired using a 3D FLASH technique, using a flip angle of 25 degrees, TR of 3.8 ms, TE of 1.8 ms using a 1 x1 x 5mm voxel size.  The 16 slice imaging set was obtained every 4.8 sec.</p><p><u><strong>DTI:</strong></u> Seventeen of the 19 patients also obtained repeat diffusion tensor imaging (DTI) sets.  Whole brain DTI were obtained using TR 6000ms, TE 100 ms, 90 degree flip angle, 4 signal averages, matrix 128 x 128,  1.72 x 1.72 x 5 mm voxel size, 12 tensor directions, iPAT 2, b value of 1000 sec/mm2 .</p><p><u><strong>Contrast‐enhanced 3D FLASH:</strong></u> All 19 patients underwent whole brain 3D FLASH imaging in the sagittal plane after the administration of Magnevist.  For this sequence, TR was 8.6 ms, TE 4.1 ms, 20 degree flip angle, 1 signal average, matrix 256 x 256; 1mm isotropic  voxel  size.</p><p><u><strong>Contrast‐enhanced 3D FLAIR:</strong></u> All 17 patients who had repeat DTI sets also had 3D FLAIR sequences in the sagittal plane after the administration of Magnevist.  For this sequence, the TR was 6000 ms, TE 353 ms, and TI 2200ms; 180 degree flip angle, 1 signal average, matrix 256 x 216; 1 mm isotropic voxel size. Note: before transmission to NCIA, all image sets with 1mm isotropic voxel size were “defaced” using MIPAV software or manually.</p><h3><br/>About the RIDER project</h3><p>The Reference Image Database to Evaluate Therapy Response (RIDER) is a targeted data collection used to generate an initial consensus on how to harmonize data collection and analysis for quantitative imaging methods applied to measure the response to drug or radiation therapy.  The National Cancer Institute (NCI) has exercised a series of contracts with specific academic sites for collection of repeat "coffee break," longitudinal phantom, and patient data for a range of imaging modalities (currently computed tomography [CT] positron emission tomography [PET] CT, dynamic contrast-enhanced magnetic resonance imaging [DCE MRI], diffusion-weighted [DW] MRI) and organ sites (currently lung, breast, and neuro). The methods for data collection, analysis, and results are described in the new Combined RIDER White Paper Report (Sept 2008):</p><ul><li><a download="RIDER-newCombined-Report.pdf" href="/wp-content/uploads/RIDER-newCombined-Report.pdf">RIDER White Paper: Combined contracts report ( Sept 2008) PDF</a></li></ul><p>The long term goal is to provide a resource to permit harmonized methods for data collection and analysis across different commercial imaging platforms to support multi-site clinical trials, using imaging as a biomarker for therapy response. Thus, the database should permit an objective comparison of methods for data collection and analysis as a national and international resource as described in the first RIDER white paper report (2006):</p><ul><li><a download="RIDER-executive-summaryA_071306.pdf" href="/wp-content/uploads/RIDER-executive-summaryA_071306.pdf"><strong>RIDER White Paper: Executive Summary PDF</strong></a></li><li><a href="https://doi.org/10.1038/clpt.2008.161"><strong>RIDER White Paper: Editorial in Nature.com</strong></a></li></ul>

RIDER神经MRI数据集收录了19名复发胶质母细胞瘤患者的影像数据，患者接受了重复成像序列。这些图像的采集间隔约为2天（除一例外，即RIDER神经MRI-1086100996患者的图像采集间隔为1天）。<p><u><strong>动态对比增强MRI（DCE-MRI）：</strong></u>所有19名患者均在相同的1.5T成像磁体上进行了重复动态对比增强MRI（DCE-MRI）数据集的采集。技术人员基于T2加权图像，采用5mm厚的连续切片，选择了16个成像位置。对于T1映射，使用5、10、15、20、25和30度的翻转角，TR为4.43毫秒，TE为2.1毫秒，2个信号平均，获得了多翻转3D FLASH图像。在注射0.1mmol/kg的Magnevist静脉注射剂3ccs/秒，扫描开始后24秒开始注射期间，获得了动态图像。使用3D FLASH技术，翻转角为25度，TR为3.8毫秒，TE为1.8毫秒，以1 x1 x 5mm的体素大小进行采集。每4.8秒获得16个切片的成像集。<p><u><strong>扩散张量成像（DTI）：</strong></u>19名患者中的17名也获得了重复扩散张量成像（DTI）集。使用TR 6000ms，TE 100 ms，90度翻转角，4个信号平均，矩阵128 x 128，1.72 x 1.72 x 5 mm的体素大小，12个张量方向，iPAT 2，b值为1000 sec/mm2进行了全脑DTI采集。<p><u><strong>对比增强3D FLASH：</strong></u>所有19名患者在接受Magnevist注射后，在矢状面上进行了全脑3D FLASH成像。对于此序列，TR为8.6毫秒，TE为4.1毫秒，翻转角为20度，1个信号平均，矩阵256 x 256；1mm各向同性体素大小。<p><u><strong>对比增强3D FLAIR：</strong></u>所有17名具有重复DTI集的患者在接受Magnevist注射后，在矢状面上也进行了3D FLAIR序列。对于此序列，TR为6000 ms，TE为353 ms，TI为2200ms；180度翻转角，1个信号平均，矩阵256 x 216；1 mm各向同性体素大小。注意：在传输至NCIA之前，所有1mm各向同性体素大小的图像集均使用MIPAV软件或手动进行了“去脸”处理。</p><h3>关于RIDER项目</h3><p>用于评估治疗效果的参考图像数据库（RIDER）是一项旨在生成关于如何统一用于测量药物或放射治疗反应的定量成像方法的数据收集和分析的初步共识的针对性数据收集。美国国家癌症研究所（NCI）与特定的学术机构签订了一系列合同，以收集重复的“咖啡休息时间”、纵向伪影和患者数据，涵盖了多种成像模式（目前包括计算机断层扫描[CT]、正电子发射断层扫描[PET]CT、动态对比增强磁共振成像[DCE MRI]、扩散加权[MW]MRI）和器官部位（目前包括肺、乳腺和神经）。数据收集、分析和结果的方法在新的RIDER联合白皮书报告中进行了描述（2008年9月）：<p><ul><li><a download="RIDER-newCombined-Report.pdf" href="/wp-content/uploads/RIDER-newCombined-Report.pdf">RIDER白皮书：联合合同报告（2008年9月）PDF</a></li></ul><p>长期目标是提供一种资源，允许在不同商业成像平台之间实现数据收集和分析的统一方法，以支持多中心临床试验，将成像作为治疗反应的生物标志物。因此，该数据库应允许作为国家级和国际级资源对数据收集和分析方法进行客观比较，如第一份RIDER白皮书报告（2006年）所述：<p><ul><li><a download="RIDER-executive-summaryA_071306.pdf" href=