LKB1 regulates adipose tissue ILC2 function through regulating mitochonrial

Our study represents LKB1 defects lead to the loss and dysfunction of adipose tissue ILC2s.And we found that LKB1 regulate ILC2s homeostasis and cytokines function in a cell-intrinsic manner.In high-diet-fed mice,LKB1 in ILC2s protects against metabolic disturbances and fat fibrosis.LKB1 deficient in ILC2 impaired the oxidative phosphorylation and led to mitochondria loss though more mitophagy. Overall design: mRNA profiles of VAT ILC2s from 14-week old wild-type male mice fed with normal diet(ND) or high-fat-diet(HFD) for 8 weeks starting at 6 weeks old