CIViC (Clinical Interpretation of Variants in Cancer)

Precision medicine refers to the use of prevention and treatment strategies that are tailored to the unique features of each individual and their disease. In the context of cancer this might involve the identification of specific mutations shown to predict response to a targeted therapy. The biomedical literature describing these associations is large and growing rapidly. Currently these interpretations exist largely in private or encumbered databases resulting in extensive repetition of effort. Realizing precision medicine will require this information to be centralized, debated and interpreted for application in the clinic. CIViC is an open access, open source, community-driven web resource for Clinical Interpretation of Variants in Cancer. Our goal is to enable precision medicine by providing an educational forum for dissemination of knowledge and active discussion of the clinical significance of cancer genome alterations.

精准医疗涉及针对每个个体及其疾病独特特征的预防和治疗方案的应用。在癌症领域，这可能包括识别特定突变，这些突变已被证实可预测对靶向疗法的反应。描述这些关联的生物医学文献数量庞大且迅速增长。目前，这些解释大多存在于私人或受限的数据库中，导致大量重复劳动。实现精准医疗需要将这些信息集中化、进行辩论和解读，以便应用于临床。CIViC是一个开放获取、开源、社区驱动的网络资源，旨在为癌症变异的临床解读提供。我们的目标是通过对癌症基因组变异临床意义的知识传播和积极讨论的教育论坛，促进精准医疗的实现。