Genome-wide association summary statistics for trail making phenotypes from UK Bioabnk, and Genes & Cognition study

This repository contains genome-wide association study (GWAS) summary statistics for the following executive function traits: Trail Making Numeric (TMN) Trail Making Alpha Numeric (TMA) Mental Plasticity (TMD = TMA − TMN) These data are derived from the study:“Genetic landscape of adult executive function reveals a cell-type specific developmental origin.” For full methodological details, please refer to the original publication at: Summary statistics are provided for: Genes and Cognition (G&C) UK Biobank (UKB) Meta-analysis (G&C + UKB) 1. Genes and Cognition (G&C) TMN: tmn_gwas_gc.txt TMA: tma_gwas_gc.txt TMD: tmd_gwas_gc.txt 2. UK Biobank (UKB) TMN: tmn_gwas_ukb.txt TMA: tma_gwas_ukb.txt TMD: tmd_gwas_ukb.txt 3. Meta-analysis TMN: tmn_meta.txt TMA: tma_meta.txt TMD: tmd_meta.txt Column Descriptions: UKB and G&C Summary Statistics SNP: rs identifier for the SNP CHR: chromosome (GRCh37 build) BP: base pair (GRCh37 build) A1: effect allele A2: reference allele A1FREQ: effect allele frequency INFO: imputation information CHISQ: Chi-square statistics P: p-value BETA: effect size of effect allele SE: standard error N: sample size Column Descriptions: Meta-analysis Summary Statistics A1: effect allele A2: reference allele A1FREQ: estimated frequency of the effect allele FreqSE: standard error of the estimated effect allele frequency MinFreq: minimum observed allele frequencies MaxFreq: maximum observed allele frequencies BETA: meta-analysed effect size SE: standard error of the meta-analysed effect size P: p-value Direction: effect direction across studies (+ / − / ?) HetISq: I² statistic (heterogeneity measure) HetChiSq: Cochran’s Q statistic HetDf: degrees of freedom for the heterogeneity test HetPVal: p-value for heterogeneity N: sample size contributing to the meta-analysis. SNP: rs identifier for the SNP CHR: chromosome (GRCh37 build) BP: base pair (GRCh37 build)